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Encompassing Amino Acids: full length
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: 50 mMTris (pH 7.5), 0.1% BSA, 20 µM substrate(A-P-AMC), and 5 ng/µl POP at roomtemperature for 30 min.
Background: Prolyl oligopeptidase (POP), also known as prolyl endopeptidase(PREP), is a cytosolic serine peptidase involved in the maturation and degradation ofpeptide hormones and neuropeptides.
Description: Human Prolyl oligopeptidase (POP)/Prolyl endopeptidase (PREP) (GenBank Accession No. NM_002726) full length with N-terminal His-tag, MW = 81.6 kDa, expressed in an E. coli expression system.
Format: Aqueous buffer solution
Formulation: 45 mM Tris-HCl, pH 8.0,124 mM NaCl, 2.4 mM KCl, 225 mMimidazole, 10% glycerol and 3 mM DTT.
Genbank: NM_002726
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag
Uniprot: P48147
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Myohanen T.T. et al., Neurochem. Res. 32(8), 1365-1374 (2007).
2. Garcia-Horsman J.A. et al., Scand. J.Gastroenterol. 42 (5), 562-571 (2007).