PROTAC BRD4 Degrader-10, CAS 2417370-49-9

Product Description: PROTAC BRD4 Degrader-10 (compound 8b) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 1.3 nM and 18 nM, respectively[1].

Applications: Cancer-programmed cell death

Formula: C59H71F2N9O15S4

References: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

CAS Number: 2417370-49-9

Molecular Weight: 1312.50

Compound Purity: 99.75

Research Area: Cancer

Solubility: DMSO : 200 mg/mL (ultrasonic)

Target: Epigenetic Reader Domain;PROTACs

• SKU: MEXHY-138633-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-138633-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK