PROTAC BRD4 Degrader-13, CAS 2417370-71-7

Product Description: PROTAC BRD4 Degrader-13 (compound 9d) is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. PROTAC BRD4 Degrader-13 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.025 nM and 6.0 nM, respectively[1].

Applications: Cancer-programmed cell death

Formula: C68H85F2N11O17P2S2

References: [1]Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

CAS Number: 2417370-71-7

Molecular Weight: 1492.54

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Epigenetic Reader Domain;PROTAC-Linker Conjugates for PAC;PROTACs

• SKU: MEXHY-138636-0
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-138636-0
• Green Labware: No
• Package Unit: Get quote
• Quantity Unit: STK