PROTAC BRD4 Degrader-5-CO-PEG3-N3, CAS 2704602-92-4

Product Description: PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker[1]. PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C58H75ClN12O12S2

References: [1]Marı A Maneiro, et al. Antibody-PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4. ACS Chem Biol. 2020 Jun 19;15(6):1306-1312.

CAS Number: 2704602-92-4

Molecular Weight: 1231.87

Compound Purity: 99.73

Research Area: Cancer

Solubility: DMSO : 20 mg/mL (ultrasonic)

Target: ADC Cytotoxin;PROTAC-Linker Conjugates for PAC

• SKU: MEXHY-133736-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-133736-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK