PSEN1 Antibody - middle region : HRP

Conjugation: HRP: Horseradish Peroxidase

Description of Target: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PSEN1

Molecular Weight: 53kDa

Peptide Sequence: Synthetic peptide located within the following region: EGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLG

Product Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

Protein Name: Presenilin-1

Protein Size: 467

Purification: Affinity Purified

• SKU: AVIARP58941_P050-HRP
• Manufacturer: Aviva Systems Biology
• Manufacturer SKU: ARP58941_P050-HRP
• Package Unit: 100μl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus), Rabbit, Dog (Canine), Guinea Pig, Cow (Bovine), Horse (Equine)
• Clonality: Polyclonal
• Application: Immunoprecipitation, Western Blotting, Immunohistochemistry
• Human Gene ID: 5663
• Host: Rabbit
• Conjugate: Conjugated, HRP