Clone Name: 4F8F11
Application Note: WB: 1:500-1:2000. ICC/IF: 1:200-1:1000. IHC-P: 1:200-1:1000. FACS: 1:200-1:400. ELISA: 1:10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 50
Form: Liquid
Buffer (with preservative): PBS, 0.05% sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot ID: P18031
Antigen Species: Human
Immunogen: Purified recombinant fragment of human PTPN1 (AA: 40-246) expressed in E. Coli.
Purification: Purified IgG1
Conjugation: Unconjugated
Full Name: protein tyrosine phosphatase non-receptor type 1
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