Storage: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Abbreviation: CD45/PTPRC
Target Synonym: B220,CD45,CD45 antigen,CD45R,CD45R0,LCA,L-CA,LY5,protein tyrosine phosphatase,receptor type,Receptor-type tyrosine-protein phosphatase C,T200,Ly-5,Ptprc,c polypeptide,CD 45,GP180,homolog of,Leukocyte common antigen,loc,Lyt-4,OTTHUMP00000033813,OTTHUMP00000033816,OTTHUMP00000033817,OTTHUMP00000038574,Protein tyrosine phosphatase receptor type c polypeptide,protein tyrosine phosphatase,receptor type,C,receptor type C,T200 glycoprotein,T200 leukocyte common antigen
Background: CD45 is a 180-240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes and platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.
Immunogen: Recombinant Mouse CD45/PTPRC protein
Buffer: PBS, pH 7.2. Contains 0.05% proclin 300.
Dilution: FCM 2 μg/mL(1×105-5×105 cells)
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