Abbreviation: PVRL1
Target Synonym: NECTIN1;CD111;CLPED1;ED4;HIgR;HV1S;HVEC;OFC7;PRR;PRR1;PVRL1;PVRR;PVRR1;SK-12;nectin-1
Conjugation: Unconjugated
UNIProt ID: Q15223
Background: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human PVRL1
Dilution: WB 1:500-1:2000
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