Abbreviation: PYCARD
Target Synonym: A; Asc; TMS-; TNS1; masc; CARD5; TMS-1; 9130417A21Rik
Conjugation: Unconjugated
UNIProt ID: Q9EPB4
Background: Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3. Involved in macrophage pyroptosis, a caspase-1-dependent inflammatory form of cell death and is the major constituent of the ASC pyroptosome which forms upon potassium depletion and rapidly recruits and activates caspase-1. In innate immune response believed to act as an integral adapter in the assembly of the inflammasome which activates caspase-1 leading to processing and secretion of proinflammatory cytokines. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of mouse PYCARD
Dilution: WB 1:500-1:2000,IHC 1:50-1:200
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