Clone Name: ARC2968
Application Note: WB: 1:500-1:2000. ICC/IF: 1:50-1:200. IP: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 24
Form: Liquid
Buffer (with preservative): PBS pH 7.3, 0.05% BSA, 50% glycerol,, 0.02% sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
Uniprot ID: P61006
Antigen Species: Human
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-207 of human RAB8A (P61006).
Purification: Purified by affinity chromatography
Conjugation: Unconjugated
Full Name: RAB8A, member RAS oncogene family
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