Rabbit anti-AKAP8/AKAP95 Antibody, Affinity Purified

Stock Concentration: 200 µg/ml

Conjugate Type: Unconjugated

Buffer: Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein ID: NP_005849.1

Uniprot ID: O43823

Background: AKAP8/AKAP95 has been characterized as a 95 kDa protein kinase A (PKA)-anchoring protein and regulatory subunit of PKA that functions to recruit the condensin complex for chromosome condensation during mitosis. A role in DNA replication has also been demonstrated through its interaction with the pre-replication complex component, MCM2 (mini-chromosome maintenance 2). Inhibition of AKAP8/AKAP95 association with MCM2 inhibits replication initiation and elongation in vitro. AKAP8/AKAP95 has also been shown to be involved in apoptosis. KAP8/AKAP95 associates with caspase 3 and serves as a carrier to transport caspase 3 from the cytoplasm to the nucleus to induce morphological changes in the nucleus.

Immunogen: Between 642 and C-terminus

• SKU: BEYA301-062A
• Manufacturer: Bethyl Laboratories
• Manufacturer SKU: A301-062A
• Green Labware: No
• Package Unit: 100 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Polyclonal
• Application: Immunoprecipitation, Western Blotting, Immunohistochemistry
• Isotype: Whole IgG
• Human Gene ID: 10270
• Host: Rabbit