Rabbit anti-DBC1/p30 DBC Antibody, Affinity Purified

Stock Concentration: 1000 µg/ml

Conjugate Type: Unconjugated

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein ID: NP_066997.3

Uniprot ID: Q8N163

Background: The DBC1 (Deleted in Breast Cancer Gene 1 protein) gene is located in a region frequently deleted in breast cancers. In its uncleaved form, DBC1 is localized to the nucleus. Upon cleavage by caspase activity, DBC1 becomes localized to the cytoplasm and functions to promote apoptosis. DBC1 has also been found to bind directly to the estrogen receptor alpha (ERalpha) hormone binding domain to modulate ERalpha expression and mediate hormone-independent breast cancer cell survival.

Immunogen: Between 675 and 725

• SKU: BEYA300-433A-T
• Manufacturer: Bethyl Laboratories
• Manufacturer SKU: A300-433A-T
• Green Labware: No
• Package Unit: 10 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Polyclonal
• Application: Immunoprecipitation, Western Blotting
• Isotype: Whole IgG
• Human Gene ID: 57805
• Host: Rabbit