Stock Concentration: 200 µg/ml
Conjugate Type: Unconjugated
Buffer: Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Shelf Life: 1 year from date of receipt
Protein ID: NP_998731.1
Uniprot ID: O00273
Background: DNA fragmentation factor (DFF45/DFFA) is a component of DFF, the principle DNA endonuclease responsible for nucleosomal DNA cleavage during apoptosis. In the DFF complex, DFF45/DFFA heterodimerizes with DFF40 and is a substrate of the apoptotic effector, caspase 3. Initiation of the cellular apoptotic program results in the activation of caspase 3 and the cleavage and release of DFF45 from its heterodimeric partner, DFF40. The release of DFF40 from the inhibitory activity of DFF45 allows DFF40 to function as a DNA endonuclease to promote chromosomal DNA fragmentation. A 35 kDa splice variant of DFF45, DFF35, also exists and functions as a chaperone and alternative heterodimeric partner for DFF40.
Immunogen: Between 281 and C-terminus
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