Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1b gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (hva) group and are blocked by omega-conotoxin-GVIA (omega-ctx-GVIA) and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to dihydropyridines (dhp), and omega-agatoxin-IVA (omega- aga-IVA). Calcium channels containing alpha-1b subunit may play a role in directed migration of immature neurons.
Positive Control: Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta.
Immunogen: Synthetic peptide derived from the rat alpha1B calcium channel conjugated to KLH
Purification Method: Ammonium Sulfate Precipitation
Concentration: See vial for concentration
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide
References: 1. Dubel, S.J. et.al. 'Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel' Proc. Natl. Acad. Sci. U.S.A. 89 (11), 5058-5062 (1992)2. Snutch,T.P.et.al. 'Rat brain expresses a heterogeneous family of calcium channels' Proc. Natl. Acad. Sci. U.S.A. 87 (9), 3391-3395 (1990)3. Hell, J.W. et.al. 'Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini' J. Biol. Chem. 269 (10), 7390-7396 (1994)4. Sunan, A.A. et.al. 'The C terminus of the Ca channel alpha1B subunit mediates selective inhibition by G-protein-coupled receptors.' J Neurosci. 21(19), 7587-97. (2001)
UniProt: Q00975
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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