Background: DDX4 is an ATP-dependent DEAD-box RNA helicase found in the chromatoid body of the germ cells (1). This enzyme is specific to germ cells and is necessary for germ cell development (2). Mouse DDX4 was shown to interact with Dicer, suggesting a role in microRNA-mediated RNA silencing (1).
Positive Control: Human testis tissue.
Immunogen: Synthetic peptide derived from the human DDX4 protein.
Purification Method: Antigen Immunoaffiinity Purification.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Kotaja, N., et al. ‘The chromatoid body of male germ cells: similarity with processing bodies and presence of Dicer and microRNA pathway components.’ Proc. Natl. Acad. Sci., 103, 2647-2652 (2006)
2. Albamonte, M.S., et al. ‘The developing human ovary: immunohistochemical analysis of germ-cell-specific VASA protein, BCL-2/BAX expression balance and apoptosis.’ Hum. Reprod. 23, 1895-1901 (2008).
UniProt: Q9NQI0.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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