Background: LASS3 (Longevity Assurance homolog 3) is a member of a highly conserved family of proteins from yeast to humans which are involved in the synthesis of ceramide. Overproduction of LASS3 appears to results in increases in several ceramide species, with some preference toward those having middle to long chain fatty acid acyl-CoAs. Also appears to have (dihydro)ceramide synthesis activity. LASS3 expression appears to be limited almost solely to the testis.
Positive Control: Expression appears to be solely limited to the testis.
Immunogen: Synthetic peptide derived from human LASS3 protein
Purification Method: Antigen Immunoaffiinity Purification
Concentration: Lot specific, see vial
Formulation: Provided as a solution in Tris buffered saline with 0.08% sodium azide, 10mM MgCl2, 10mM ammonium sulfate, and 0.2% lactose.
References: Mizutani, Y., et al. 'LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity.' Biochem. J., 2006, 398, 531-538.
UniProt: Q8IU89
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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