Background: Protein phosphatase 2A (PP2A) is a hetertrimeric enzyme consisting of a catalytic subunits (C), a structural subunit (A) and a variable regulatory subunit (B). The B subunit family is made up of the , and isoforms. The PP2A/B isoform appears to only be detectable in the brain where it has been speculated that it cytoskeletal substrates. The RNA which produces the PP2A/B is developmentally regulated and increases sharply after birth. It has also been suggested that it may be important in the establishment and maintenance of neuronal connections.
Immunogen: Antibody raised against synthetic peptide corresponding to amino acids 53 to 66 of the mammalian protein phosphatase 2 A/B conjugated to KLH.
Purification Method: Ammonium Sulfate Precipitation.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Strack, S., et al. Brain protein phosphatase 2A: Developmental regulation and distinct cellular and subcellular localization by B subunits. J. Comp. Neurol. 1998, 392, 515-527.
UniProt: Q13362 (Human)
P97888 (Rat)
Q8BG02 (Mouse).
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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