Rabbit anti-PHD3 Antibody, Affinity Purified

Stock Concentration: 1000 µg/ml

Conjugate Type: Unconjugated

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Shelf Life: 1 year from date of receipt

Protein ID: NP_071356.1

Uniprot ID: Q9H6Z9

Background: PHD3 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.

Immunogen: Between 50 and 100

• SKU: BEYA300-327A-T
• Manufacturer: Bethyl Laboratories
• Manufacturer SKU: A300-327A-T
• Green Labware: No
• Package Unit: 10 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Polyclonal
• Application: Western Blotting
• Isotype: Whole IgG
• Human Gene ID: 112399
• Host: Rabbit