Background: In neurons voltage-dependent potassium channels are key determinants of the resting membrane potential and of membrane excitability, conditioning the frequency, and shape of action potential (1). Potassium channels are encoded by numerous genes whose products can be classified into distinct subfamilies. The most distinctively characterized is that of the Kv1 shaker class (2).
Purification Method: Ammonium Sulfate Precipitation.
Source: Rabbits were immunized with a peptide derived from rat Kv1.4 potassium channel protein, conjugated to KLH.
References: 1) Miller C. Science 1991: 252;1092-1096
2) Chandy K.G. et al. Handbook of receptors and channels. CRC Press 1995; 1-71.
3) Jugloff J.G.M. et al. J. Biol. Chem. 2000: 275; 1357-1364.
UniProt: P15385.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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