Clone Number: EP32
Immunogen: A synthetic peptide corresponding to residues of human S100 Beta protein.
Concentration: Greater than or equal to 30 mg/L
Storage buffer: Tissue culture supernatant with sodium azide
Additional info: S-100A and S-100B proteins are two members of the S-100 family of proteins. S-100A subtypes are composed of one alpha and one beta chain, whereas S-100B is composed of two beta chains. S-100 protein is reported to be expressed in neuroectodermal tissue, including nerves and melanocytes. Langerhans cells in skin are also reported to express S-100 protein. It is noteworthy that S-100 protein is highly soluble and may be eluted from frozen tissue during immunohistochemical procedures. Clone EP32 was raised against S-100 beta protein. Immunoreactivity was observed in neuroectodermal tissue e.g. melanocytes, nerve fibres, dendritic cells, adipocytes and a percentage of macrophages, lymphocytes and plasma cells.
References: Chen H et al. American Journal of Cancer Research 2014;4(2):89-115/Torlakovic EE et al.Applied Immunohistochemistry & Molecular Morphology. 2015; 23(1):1-18
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