Clone Number: M6II-31
Immunogen: ABCC6 aa 764-964
Concentration: 50 ug/ ml
Storage buffer: supernatant with 0.7% BSA and 0.1% sodium azide
Additional info: M6II-31 reacts with MRP6, a 190-200 kD transmembrane protein that is related to the multidrug resistance related protein MRP. Mutations in the MRP6 gene are responsible for the connective tissue disorder Pseudoxanthoma elasticum (PXE). M6II-31 was raised against a bacterial fusion protein of human MRP6, containing amino acids 764-964, spanning the putative 12th transmembrane region as well as predicted internal and external regions of the protein. M6II-31 did not cross-react with the human MDR1, MRP1, MRP2, MRP3, MRP4, MRP5 gene products.
References: Bergen AA et al. Nat Genet 2000; 25: 228-231/Scheffer GL et al. Lab Invest 2002; 82: 515-518