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Encompassing Amino Acids: 65-402 (end)
Assay Conditions: Assay was performedusing BPS's Renin Assay kit, cat. # 80211, following the recommended assay protocol.
Background: Renin is a protease that is synthesized by the kidneys. Renin catalyzesthe hydrolysis of angiotensinogen to angiotensin I, which is converted to angiotensin II, ahighly potent vasoconstrictor. Renin inhibitors have been used therapeutically in thetreatment of hypertension (high blood pressure).
Description: Rat, Activated Renin (GenBank Accession No. NM_012642), a.a. 65 - 402 (end) with C-terminal His-tag, MW=38.5 kDa, expressed in an HEK293 cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol.
Genbank: NM_012642
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal His-tag
Uniprot: P08424
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Kedrah, AE., et al., Kidney Blood Press Res. 2012 Jun 6;35(6):425-430.
2. Burnham, CE., et al., Proc Natl Acad Sci USA. 1987 Aug;84(16):5605-5609.
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