Abbreviation: IGF1;IGF-1
Target Synonym: Insulin-like growth factor I;IGF1;
Target Species: Chicken
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: P18254
Background: Insulin-like growth factor I (IGF-I or IGF-1), also known as somatomedin C, is the dominant effector of growth hormone and is structurally homologous to proinsulin. IGF-I induces the proliferation, migration, and differentiation of a wide variety of cell types during development and postnatally . IGF-I regulates glucose and fatty acid metabolism, steroid hormone activity, and cartilage and bone metabolism . It plays an important role in muscle regeneration and tumor progression . IGF-I/IGF-1 binds IGF-I R, IGF-II R, and the insulin receptor, although its effects are mediated primarily by IGF-I R . The IGF-I protein associates with IGF binding proteins thereby increasing its plasma half?life and modulating its interactions with receptors.
Sequence: Gly 49-Met 153
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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