Abbreviation: ABL1
Target Synonym: Abelson tyrosine protein kinase 1;ABL 1;bcr/abl;JTK7;p150;Proto-oncogene c-Abl;v abl
Target Species: Cynomolgus macaques
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: A0A2K5X6F2
Background: Protein kinase that regulates key processes linked to cell growth and survival. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
Sequence: Met 1-Phe 264
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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