Recombinant Human BDNF protein (His tag)

Abbreviation: BDNF

Target Synonym: Brain-Derived Neurotrophic Factor;BDNF;Abrineurin

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P23560

Background: The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis; whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival; growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects; Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

Sequence: His 129-Arg 247

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• SKU: ELSPDEH100216-100
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDEH100216-100
• Package Unit: 100 µg
• Quantity Unit: STK