Abbreviation: BRCA2
Target Synonym: BRCA 2;BRCA1/BRCA2 containing complex subunit 2;Brca2;BRCA2;DNA repair associated;BRCA2;BRCC 2;BRCC2;Breast and ovarian cancer susceptibility gene early onset;breast and ovarian cancer susceptibility protein 2;Breast cancer 2 early onset;Breast Cancer 2 tumor suppressor;Breast cancer susceptibility protein BRCA2;Breast cancer type 2 susceptibility protein;BROVCA2;FACD;FAD 1;FAD;FAD1;FANCB;FANCD 1;FANCD;FANCD1;FANCD1 gene;Fanconi anemia complementation group D1;Fanconi anemia group D1 protein;GLM3;mutant BRCA2;OTTHUMP00000018803;OTTHUMP00000042401;PNCA2;XRCC11
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: P51587
Background: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Activity: Immunogen(E-AB-40288)
Sequence: Thr2350-Val2545
Purity: > 85 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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