Description: The IGFs, or insulin-like growth factors, are polypeptide growth factors known for their ability to stimulate the proliferation and survival of various cell types, including those found in muscle, bone, and cartilage tissue when studied in vitro. While primarily synthesized in the liver, different tissues produce IGFs at specific times. Belonging to the Insulin gene family, which also includes insulin and relaxin, IGFs share structural and functional similarities with insulin but exhibit significantly greater growth-promoting activity. IGF-II expression is influenced by placenta lactogen, while growth hormone regulates IGF-I expression. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), though IGF-II can also utilize the IGF-II/Mannose-6-phosphate receptor pathway. Mature IGFs are formed through proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
Molecular Weight: 9.1 kDa
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Gene Symbol: IGF1
Protein ID: P05019
English
Deutsch
