Description: IL-10, an immunosuppressive cytokine, is synthesized by various mammalian cell types like macrophages, monocytes, T cells, B cells, and keratinocytes. Its primary function is to dampen the expression of proinflammatory cytokines such as IL-1 and TNF-α. Similar to IL-4, IL-10 boosts humoral immune responses while tempering cell-mediated immune reactions. Interestingly, Human IL-10 exhibits activity on murine cells, but the reverse is not true-murine IL-10 doesn't affect Human cells. The recombinant Human IL-10, a protein weighing 18.6 kDa and comprising 161 amino acid residues, reflects these immunomodulatory properties.
Expression System: E. coli
Molecular Weight: 18.6 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: IL10
Protein ID: P22301
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