Description: IL-4, a multifaceted cytokine, plays a crucial role in governing various T and B cell activities such as cell proliferation, survival, and gene expression. It is synthesized by mast cells, T cells, and bone marrow stromal cells. IL-4 specifically directs the transformation of naive CD4+ T cells into helper Th2 cells, known for their cytokine-secretion profile that includes IL-4, IL-5, IL-6, IL-10, and IL-13, all conducive to a humoral immune response. Additionally, IL-4 is pivotal in regulating the shift of immunoglobulin classes towards IgG1 and IgE isotypes. An important note is that excessive IL-4 production by Th2 cells can lead to heightened IgE production and allergic responses. The recombinant Human IL-4, a 15.1 kDa globular protein containing 130 amino acid residues, mirrors these regulatory functions in the immune system.
Expression System: E. coli
Molecular Weight: 15.1 kDa
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10^6 units/mg.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: IL4
Protein ID: P05112
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