Description: M-CSF, a potent hematopoietic factor, is generated by a variety of cells such as lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. It serves as a crucial regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their progenitor cells. Notably, M-CSF plays significant roles in modulating dermal thickness and fertility. Clinically, it finds use in treating infections, malignancies, and atherosclerosis, aiding hematopoietic recovery post bone marrow transplantation. While Human M-CSF is reactive in murine systems, the murine molecule lacks activity on Human cells. Recombinant Human M-CSF is a homodimeric protein weighing 36.8 kDa, composed of two 159 amino acid polypeptide subunits. M-CSF, a potent hematopoietic factor, is generated by a variety of cells such as lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. It serves as a crucial regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their progenitor cells. Notably, M-CSF plays significant roles in modulating dermal thickness and fertility. Clinically, it finds use in treating infections, malignancies, and atherosclerosis, aiding hematopoietic recovery post bone marrow transplantation. While Human M-CSF is reactive in murine systems, the murine molecule lacks activity on Human cells. Recombinant Human M-CSF is a homodimeric protein weighing 36.8 kDa, composed of two 159 amino acid polypeptide subunits. M-CSF, a potent hematopoietic factor, is generated by a variety of cells such as lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. It serves as a crucial regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their progenitor cells. Notably, M-CSF plays significant roles in modulating dermal thickness and fertility. Clinically, it finds use in treating infections, malignancies, and atherosclerosis, aiding hematopoietic recovery post bone marrow transplantation. While Human M-CSF is reactive in murine systems, the murine molecule lacks activity on Human cells. Recombinant Human M-CSF is a homodimeric protein weighing 36.8 kDa, composed of two 159 amino acid polypeptide subunits.
Expression System: E. coli
Molecular Weight: 36.8 kda
Class: Recombinant
Endotoxin Concentration: <1 EU/µg
Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.
Form: Lyophilized
Contains: no preservative
Storage Conditions: -20°C
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses
Caution: For Research Use Only. Not for use in diagnostic procedures.
Gene Symbol: CSF1
Protein ID: P09603
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