Abbreviation: Merlin;NF2
Target Synonym: CAN;BANF;Bilateral acoustic neuroma;MERL_HUMAN;Merlin;Moesin ezrin radixin like protein;Moesin ezrin radizin like;Moesin-ezrin-radixin-like;Neurofibromatosis 2;Neurofibromatosis type 2;Neurofibromatosis2;NF 2;SCH;Schwannomerlin
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: P35240
Background: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Activity: Immunogen(E-AB-40336)
Sequence: Met1-Leu595
Purity: > 90 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4., 5% trehalose, 5% mannitol, 0.01% tween-80.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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