Recombinant Human MICB Protein (His Tag)(Active)

Abbreviation: MICB

Target Synonym: PERB11.2

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-His

UNIProt ID: Q29980

Background: MHC class I polypeptide-related sequence B; also known as MICB; is a heavily glycosylated protein serving as a ligand for the type I I receptor NKG2D. MICB shares 85% amino acid identity with MICA; a closely related protein; both of which contain three extracellular immunoglobulin-like domains; but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen; binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells; CD8+αβ T cells; and γδ T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells; but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance; viral infections; and autoimmune diseases.

Activity: Immobilized human MICB-His at 10 ug/ml (100 ul/well) can bind human NKG2D, The EC50 of human NKG2D is 0.52-1. 2 ug/ml.

Sequence: Met 1-Gly 298

Purity: > 98 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method.

• SKU: ELSPDMH100004-20
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDMH100004-20
• Green Labware: No
• Package Unit: 20 µg
• Quantity Unit: STK
• Application: ELISA