Recombinant Human NANOG protein (His tag)

Abbreviation: NANOG

Target Synonym: Embryonic stem cell specific homeobox protein;ENK;FLJ12581;hNanog;Homeobox protein NANOG

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: Q9H9S0

Background: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation.

Sequence: Lys 94-Ser 162

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• SKU: ELSPDEH100248-20
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDEH100248-20
• Green Labware: No
• Package Unit: 20 µg
• Quantity Unit: STK