Abbreviation: P21
Target Synonym: CAP20;CDK-interacting protein 1;CDKI;CDKN1;CDN1A;CIP1;CDKN1A;Cyclin Dependent Kinase Inhibitor 1A;DNA Synthesis Inhibitor;MDA-6;MDA6;Melanoma differentiation-associated protein 6;P21cip1;P21waf;PIC1;SDI1;SLC12A9;WAF1
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: P38936
Background: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Sequence: Gly 40-Pro 164
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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