Abbreviation: PLGF;PGF
Target Synonym: PlGF2;PlGF-2;PGF;PLGF;PlGF2;PlGF;PGFL
Target Species: Human
Expression Host: E.coli
Fusion Tag: C-His
UNIProt ID: P49763
Background: Placental growth factor is a protein that in humans is encoded by the PGF gene. It is a secreted protein and belongs to the PDGF/VEGF growth factor family. Alternate splicing results in at least three human mature PlGF forms containing 131 (PlGF?1), 152 (PlGF?2), and 203 (PlGF?3) amino acids (aa) respectively. PlGF is mainly found as a variably glycosylated, secreted, 55 ? 60 kDa disulfide linked homodimer.The protein is a member of the VEGF (vascular endothelial growth factor) sub-family-a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PlGF (especially PlGF?1) and some forms of VEGF can form dimers that decrease the angiogenic effect of VEGF on VEGF R2. PlGF?2, like VEGF164/165, shows heparin?dependent binding of neuropilin (Npn)?1 and Npn?2, and can inhibit nerve growth cone collapse. Circulating PlGF often correlates with tumor stage and aggressiveness, and therapeutic PlGF?2 antibodies are being investigated for their ability to inhibit tumor growth and angiogenesis.
Sequence: Leu 19-Arg 149
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
English
Deutsch
