Abbreviation: PODXL
Target Synonym: PCLP;PCLP1;PCLP-1;PCLPGCTM-2 antigen;PCpodocalyxin;POD XL;Podocalyxin;Podocalyxin-like protein 1;podocalyxin-like;PODXL
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-SUMO-His
UNIProt ID: O00592
Background: Podocalyxin (PODXL), also known as Podocalyxin-like protein 1 (PCLP-1), is a heavily glycosylated transmembrane sialoprotein in the CD34 and Endoglycan family.Podocalyxin is expressed on glomerular and vascular endothelial cells, neurons, hematopoietic, mesenchymal, and cardiac stem cells, and metastatic carcinoma and glioblastoma tumor cells. A soluble form of Podocalyxin can be released into the urine of women with pre-eclampsia. Podocalyxin promotes platelet activation, neurite outgrowth, branching, and synaptogenesis, homing of hematopoietic progenitor cells to the bone marrow and spleen, and engraftment of mesenchymal and cardiac stem cells into ischemic heart and kidney. Its interactions with L-Selectin and E-Selectin mediate the tethering of lymphocytes and metastatic tumor cells to the vascular endothelium.
Sequence: Ala 220-Ile 431
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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