Abbreviation: PTEN
Target Synonym: 10q23del;BZS;DEC;GLM2;MGC11227;MHAM;MMAC1;MMAC1 phosphatase and tensin homolog deleted on chromosome 10;Mutated in multiple advanced cancers 1;Phosphatase and tensin homolog;Phosphatase and tensin like protein;Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN;Pten;PTEN;PTEN1;TEP1
Target Species: Human
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: P60484
Background: PTEN (also designated MMAC1),products of tumor suppressor genes,are found deleted in most human gliomas. The PTEN genes are also mutated in many other tumors,such as brain,breast,kidney and prostate cancers. PTEN is a protein tyrosine phosphatase that may terminate the signaling transduction pathways mediated by PI 3-kinase/Akt. PTEN has an apparent molecular weight of 55 kDa and it is located in the cytosol.
Sequence: Thr2-Val403
Purity: > 85 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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