Abbreviation: Galectin-3;Lgals3
Target Synonym: 35 kDa lectin;Carbohydrate binding protein 35;CBP35;GAL3;GALBP;GALIG;GBP;Gal-3;IgE binding protein;LGALS2;Macrophage galactose-specific lectin;Lectin L-29;Mac-2 antigen
Target Species: Mouse
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: P16110
Background: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes.
Activity: Immunogen(E-AB-40350)
Sequence: Ala2-Ile264
Purity: > 90 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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