Abbreviation: S100a8
Target Synonym: 60B8AG;CAGA;Calgranulin A;Calprotectin L1L subunit;CFAG;CGLA;CP 10;Cystic fibrosis antigen;L1Ag;MA387;MIF;MRP-8;MRP8;NIF;P8;Protein S100-A8;S100A8;Urinary stone protein band A;Pro-inflammatory S100 cytokine;S100 calcium-binding protein A8
Target Species: Mouse
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: P27005
Background: S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration.
Activity: Immunogen(E-AB-40356)
Sequence: Pro2-Glu89
Purity: > 90 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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