Abbreviation: S100a9
Target Synonym: Leukocyte L1 complex heavy chain;60B8AG;CAGB;Calgranulin B;Calgranulin-B;Calprotectin L1H subunit;CFAG;CGLB;Cystic fibrosis antigen B;L1AG;Leukocyte L1 complex heavy chain;LIAG;MAC387;MIF;Migration inhibitory factor related protein 14;Migration inhibitory factor-related protein 14;MRP 14;MRP-14;MRP14;Myeloid-related protein 14;NIF;OTTHUMP00000015331;p14;Protein S100-A9;S100 A9;S100 calcium binding protein A9;S100 calcium binding protein A9 calgranulin B;S100 calcium-binding protein A9;S100A9;S10A9
Target Species: Mouse
Expression Host: E.coli
Fusion Tag: N-His & C-His
UNIProt ID: P31725
Background: S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.
Activity: Immunogen(E-AB-40341)
Sequence: Ala2-Lys113
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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