Abbreviation: AIF-M1
Target Synonym: AIFM1;Apoptosis inducing factor 1;mitochondrial;Apoptosis inducing factor;CMTX4;COWCK;COXPD6;Harlequin;mitochondrial;PDCD 8;Programmed cell death 8;Striatal apoptosis inducing factor
Target Species: Rat
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: Q9JM53
Background: Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner.
Sequence: Arg 150-Val 299
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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