Abbreviation: AST
Target Synonym: Aspartate aminotransferase;cytoplasmic;cAspAT;Cysteine aminotransferase;cytoplasmic;Cysteine transaminase;cytoplasmic;cCAT;Glutamate oxaloacetate transaminase 1;Transaminase A;Got1
Target Species: Rat
Expression Host: HEK293 Cells
Fusion Tag: C-His
UNIProt ID: P13221
Background: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Sequence: Met1-Gln413
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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