Recombinant Rat CD22/Siglec-2 protein (His tag)

Abbreviation: CD22;Siglec-2

Target Synonym: CD22 antigen;Cd22;

Target Species: Rat

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: D3ZD88

Background: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Sequence: Trp 24-Thr 331

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• SKU: ELSPDER100092-20
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDER100092-20
• Package Unit: 20 µg
• Quantity Unit: STK