Abbreviation: Occludin;OCLN
Target Synonym: Occludin;OCLN_RAT;
Target Species: Rat
Expression Host: E.coli
Fusion Tag: N-His
UNIProt ID: Q6P6T5
Background: Rat Occludin is a 523 amino acid (aa), predicted molecular weight 59 kDa integral membrane protein that localizes within tight junctions of epithelial and endothelial cells. May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. May be involved in the organization of actin in endothelial cells. Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG); also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.
Sequence: Lys266-Thr522
Purity: > 95 % as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Endotoxin: Please contact us for more information.
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