Recombinant Rat TNF-alphasf protein(His tag)

Abbreviation: TNF-αsf

Target Synonym: Cachectin;TNF-alpha;Tumor necrosis factor ligand superfamily member 2;TNF-a;N-terminal fragment;NTF;ICD1;ICD2

Target Species: Rat

Expression Host: E.coli

Fusion Tag: N-His

UNIProt ID: P16599

Background: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance.Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.

Sequence: Gly57-Leu235

Purity: > 85 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Endotoxin: Please contact us for more information.

• SKU: ELSPDER100019-20
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-PDER100019-20
• Package Unit: 20 µg
• Quantity Unit: STK