Application Note: Interferon-alpha 2b Recombinant Protein has been tested by SDS-PAGE and is suitable as a control for polyclonal or monoclonal anti-Interferon-alpha 2b in immunological assays.
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Other Performance Data: Endotoxin Level: Measured by kinetic LAL analysis and is typically ≤ 1 EU/μg protein. Biologic Activity: The activity is determined by the ability induce antiviral activity.
Physical State: Lyophilized
Purity and Specificity: Interferon-alpha 2b purity was determined to be greater than 98% as determined by HpLC and by reducing and non-reducing SDS-pAGE.
Background: Interferon-alpha 2b (IFNα 2b) is a Type I interferon made by leukocytes during viral infection. It has anti-viral and non-proliferative activity induced by JAK1-STAT signaling. IFN-alphas are the most widely used type for therapeutic purposes. IFNα 2b is a variant of IFNα 2a that differs by one amino acid. Recombinant human IFNα 2b is a non-glycosylated protein, containing 166 amino acids, with a molecular weight of 19.4 kDa.
Low Endotoxin: Yes
Other: User Optimized
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