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Encompassing Amino Acids: Full Length
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: RIPK5 is a dual specificity serine/threonine and tyrosine protein kinase that is a member of the RIPK family. RIPK5 is widely expressed in vertebrates with broad distributed in the central nervous system, and deregulated in certain human cancers (1). RIPK5 has been shown to function as a regulator of cell death. Overexpression of RIPK5 leads to cell death as evidenced by DNA fragmentation (2). RIPK5 induces both caspase-dependent and caspase-independent cell death, and N- and C-terminal RIPK5 deletion mutants retained the ability to induce cell death.
Description: Human RIPK5, also known as DSTYK, DustyPK, HDCMD38P, KIAA0472, and RIP5, GenBank Accession No. NM_015375, a.a. full length, with N-terminal GST-tag, expressed in a Baculovirus-infected Sf9 cell expression system. MW = 140 kDa.
Format: Aqueous buffer solution.
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Genbank: NM_015375
Purity: ≥85%
Storage Stability: At least 6 months at –80°C.
Tags: N-terminal GST-Tag
Uniprot: Q6XUX3
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Peng, J. et al., Biochem. Biophys. Acta. 1759(11-12): 562-72.., 2006.
2. Zha, J. et al., Biochem., Biophys. Res. Commun. 319: 298-303, 2004.
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