Application Note: Epstein-Barr Virus Induced Gene 3 Recombinant Protein has been tested by SDS-PAGE and is suitable as a control for polyclonal or monoclonal anti-Epstein-Barr Virus Induced Gene 3 in immunological assays.
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Other Performance Data: Endotoxin Level: Measured by kinetic LAL analysis and is typically ≤ 1 EU/μg protein. Biologic Activity: Assay data for recombinant mouse EBI3 is based upon qualitative binding to anti-EBI3 antibody.
Physical State: Lyophilized
Purity and Specificity: Epstein-Barr Virus Induced Gene 3 purity was determined to be greater than 90% as determined by analysis by UV-Spectroscopy at 280nm and by reducing and non-reducing SDS-pAGE.
Background: Epstein-Barr Virus Induced Gene-3 (EBI3), is a secreted glycoprotein belonging to the hematopoietin receptor family and is related to the p40 subunit of IL-12. EBI3 was identified by its induced expression in B-lymphocytes in response to Epstein-Barr virus infection. EBI3 forms heterodimers with p28 to form IL-27 and with p35 to form IL-35. Both IL-27 and IL-35 have anti-inflammatory and regulatory activity. Recombinant mouse EBI3 is a non-glycosylated protein, containing 207 amino acids, with a molecular weight of 22.9 kDa.
Low Endotoxin: Yes
Other: User Optimized
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