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Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: ROCK1 is a ubiquitously expressed serine/threonine kinase that is a downstream target of the small GTPase RhoA. ROCK1 is involved in diverse cellular functions, including smooth muscle contraction, actin cytoskeleton organization, cell adhesion and motility, and gene expression. ROCK1 contributes to the development of cardiac fibrosis and induction of fibrogenic cytokines in cardiomyocytes in response to pathological stimuli. ROCK1 knockout mice exhibit reduced perivascular and interstitial fibrosis which is associated with reduced expression of a variety of extracellular matrix (ECM) proteins and fibrogenic cytokines.
Description: The ROCK1 Kinase Assay Kit is designed to measure ROCK1 activity for screening and profiling applications using ADP-Glo® as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The ROCK1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified ROCK1, substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Uniprot: Q13464
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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