Application Note: Anti-Setd1a Antibody has been tested by ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 186 kDa in the appropriate cell lysate or extract.
Concentration Value: neat
ELISA Dilution: 1:100
Western Blot Dilution: 1:500
General Disclaimer Note: This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
Immunogen: Anti-Setd1a Antibody was produced in rabbits by repeated immunizations with three different synthetic peptides of mouse Setd1a: two containing an amino acid sequence from the N-terminal region of the protein and one containing an amino acid sequence from the internal region of the protein.
Physical State: Liquid (sterile filtered)
Purity and Specificity: Anti-Setd1a Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. Cross reactivity with Setd1a from other species not tested.
Background: SETD1A is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional activation. SETD1A shows a non-overlapping localization with SETD1B, suggesting that both proteins play a specific role in the epigenetic control of chromatin structure and gene expression. Anti-Setd1a Antibody is ideal for research in Epigenetics and Gene Expression.
Low Endotoxin: No
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